Diamide analogues of phosphatidyl choline as potential anti-AIDS agents

Abstract

Acylation of 3-tetrahydropyran-2-yloxypropane-1,2-diamine with dodecanoyl chloride (lauroyl chloride) and hexadecanoyl chloride (palmitoyl chloride) followed by O-deprotection afforded racemic diamide analogues of 1,2-diglycerides which were converted by sequential treatment with 2-chloro-1,3,2-dioxaphospholan-2-one and trimethylamine into the corresponding diamide analogues of phosphatidyl choline. One of these compounds shows moderate anti-HIV activity.