First total synthesis of (±)-peridinin, (±)-pyrrhoxanthin and the optically active peridinin

Abstract

The first total synthesis of peridinin 1 and pyrrhoxanthin 2 has been accomplished via the reaction of the C₁₅-epoxy formyl ester 21 with the C₂₂-allenic sulfone 28 or the C₂₂-acetylenic sulfone 39. A synthesis of optically active peridinin has also been achieved starting from the (4R,6R)-hydroxy ketone 5.