Synthesis of α-alkyl-α-benzyl amino acid derivatives, via the diastereoselective alkylation of (3S,5R)-N,3-dibenzyl-3,4,5,6-tetrahydro-5-phenyl-1,4-oxazin-2-one
Abstract
(3S,5R)-N,3-Dibenzyl-3,4,5.6-tetrahydro-5-phenyl-1,4-oxazin-2-one, derived from L-phenylalanine and phenacyl bromide, was alkylated in a diastereoselective manner to give a range of α-alkylated phenylalanine derivatives.