Catalytic hydrolysis of 2′,3′-cyclic adenosine monophosphate by aqua(2,2′:6′,2″-terpyridine)copper(II): breakdown of the analogy between activated phosphodiesters and RNA

Abstract

Aqua(2,2′:6′,2″-terpyridine)copper(II) catalyses the hydrolysis of 2′,3′-cyclic adenosine monophosphate, but does not hydrolyse the ‘activated’ substrate bis(p-nitrophenyl) phosphate indicating that the latter is not a reliable model for biological phosphoric ester hydrolysis.