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Issue 22, 1993
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Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

Abstract

Complexes of CuII, FeIII, CoII, NiII, TiIV and ZnII with 3,5-disubstituted salicylates, and ternary complexes of CuII containing substituted phenanthrolines have been prepared and characterised. The crystal structure of bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II), [Cu(phen)(Hdips)2], has been determined; CuII is in a tetragonal co-ordination environment with in-plane bonds to 2 nitrogens from phen[Cu–N 2.014(4)Å] and 2 oxygens from the carboxylates of Hdips [Cu–O 1.951(3)Å], with weaker off-axial bonds to carboxylate oxygens [Cu–O 2.557(3)Å]. The hydroxyl oxygen of Hdips is not co-ordinated. These complexes have been tested for antiviral and cytotoxic activity. Most are potently cytotoxic, especially [Cu(dmphen)(Hdips)2], where dmphen is 2,9-dimethylphenanthroline.

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Article information


J. Chem. Soc., Dalton Trans., 1993, 3393-3399
Article type
Paper

Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

J. D. Ranford, P. J. Sadler and D. A. Tocher, J. Chem. Soc., Dalton Trans., 1993, 3393
DOI: 10.1039/DT9930003393

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