Micelle-induced release of haem–NO from nitric oxide complex of myoglobin
Abstract
The cleavage of the haem-proximal histidine bond and concomitant release of haem–NO from MbNO has been achieved at physiological pH by aqueous micelles such as hexadecyltrimethyl ammonium bromide and sodium dodecyl sulfate, and the released haem–NO complex is encapsulated in the hydrophobic micellar cavity; this micellar effect has close similarity with the action of guanyl cyclase on nitrosyl haem proteins.