The novel enyne-allene sulfones 5–8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1–4; the enyne-allene sulfones 6–8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)viathe allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.
K. Toshima, K. Ohta, A. Ohtsuka, S. Matsumura and M. Nakata, J. Chem. Soc., Chem. Commun., 1993, 1406 DOI: 10.1039/C39930001406
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