Decomposition of the antitumour drug temozolomide in deuteriated phosphate buffer: methyl group transfer is accompanied by deuterium exchange
Abstract
The antitumour prodrug temozolomide 1 undergoes ring-opening in deuteriated phosphate buffer; deuterium incorporation into the methyl group transferred from the reactive species 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC)2has been monitored by observing D–H and P–H couplings in the NMR spectra of the products.