Very mild and efficient one-pot access to the valuable 2-hydroxybicyclo[3.2.1]octan-8-one ring system
Abstract
Cyclic β-ketoesters undergo, in a one-pot process, a facile tandem Michael addition–regioselective aldol cyclization with α,β-unsaturated aldehydes in acetone at room temperature in the presence of 1.5 equiv. of K2CO3 to afford 2-hydroxybicyclo[3.2.1]octan-8-ones in synthetically useful yields.