Reaction of 1,3,3-trihalo-7-oxabicyclo[4.1.0]heptanes with boron trifluoride–ether or HF· pyridine resulted in the regio-and stereo-selective formation in high yield of the corresponding cis-fluorohydrins; using a succession of cyclisations followed by ring-opening reactions by fluoride afforded an iterative preparation of unknown 2,2,6,6-tetrafluorocyclohexanol 13 starting from the chlorinated analogue 1.
P. Duhamel, B. Leblond and J. Poirier, J. Chem. Soc., Chem. Commun., 1993, 476 DOI: 10.1039/C39930000476
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