Efficient synthesis of 3H,5H-pyrrolo[3,2-d]pyrimidin-4-one
Abstract
Palladium-catalysd cross-coupling of 4-iodo-6-methoxy-5-nitropyrimidine and trimethyl(tributylstannylethynyl)silane to form the corresponding 4-trimethylsilylethynylpyrimidine and subsequent construction of an annellated pyrrolo ring provides an efficient route to the pyrrolo[3,2-d]pyrimidine system.