Palladium-catalysd cross-coupling of 4-iodo-6-methoxy-5-nitropyrimidine and trimethyl(tributylstannylethynyl)silane to form the corresponding 4-trimethylsilylethynylpyrimidine and subsequent construction of an annellated pyrrolo ring provides an efficient route to the pyrrolo[3,2-d]pyrimidine system.
M. Brakta and G. D. Daves, J. Chem. Soc., Perkin Trans. 1, 1992, 1883 DOI: 10.1039/P19920001883
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