The highly oxygenated α-tropolone antibiotic 3,4-dimethoxy-α-tropolone 3 has been synthesized in a fully regiocontrolled manner from commercially available cis-1,2-dihydrocatechol 5. Demethylation of 3,4-dimethoxy-α-tropolone 3 produced the potent antitumour agent 3,4-dihydroxy-α-tropolone 4.
M. G. Banwell, M. Corbett, M. F. Mackay and S. L. Richards, J. Chem. Soc., Perkin Trans. 1, 1992, 1329 DOI: 10.1039/P19920001329
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