Issue 5, 1992

Synthesis of 6-hydroximino-3-oxo steroids, a new class of aromatase inhibitor

Abstract

(E)-3β,17β-Dihydroxyandrost-4-en-6-one oxime has been converted into (E)-6- hydroximinotestosterone and (E)-6-hydroximinoandrost-4-ene-3,17-dione by chemical methods, and into (E)-6-hydroximinoandrosta-1,4-diene-3,17-dione by biotransformation using Arthrobacter simplex ATCC 6946.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 585-587

Synthesis of 6-hydroximino-3-oxo steroids, a new class of aromatase inhibitor

H. L. Holland, S. Kumaresan, L. Tan and V. C. O. Njar, J. Chem. Soc., Perkin Trans. 1, 1992, 585 DOI: 10.1039/P19920000585

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