A short new route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available quinoline precursors involving two key steps: (i) a palladium(0)-catalysed Suzuki cross-coupling reaction of 4-chloroquinolines with arylboronic acids, and (ii) an intramolecular nitrene insertion reaction of the nitrenes derived from 4-phenyl-5-azidoquinolines.
N. M. Ali, S. K. Chattopadhyay, A. McKillop, R. M. Perret-Gentil, T. Ozturk and R. A. Rebelo, J. Chem. Soc., Chem. Commun., 1992, 1453 DOI: 10.1039/C39920001453
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