At equilibrium in acidic solution the succinimide derivative, formed by cyclization reaction of the Asp side chain, predominates; at a pH close to the apparent pKa of the Asp residue this reaction is relatively fast with a t1/2 of a few days.
S. Capasso, L. Mazzarella, F. Sica, A. Zagari and S. Salvadori, J. Chem. Soc., Chem. Commun., 1992, 919 DOI: 10.1039/C39920000919
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