Synthesis and structure of a new type of polycyclic peptide
Abstract
The synthesis of a ‘polycyclic peptide’ is described, in which the ε-nitrogens of cyclo-(Lys-Lys-Gly)2 are interconnected by four p-xylyl moieties; this is the first example of the use of multiple cross-linking to generate highly constrained peptides, and NMR spectroscopic evidence indicates the presence of two unusual β-turns that are predicted from molecular modelling studies.