Chemoselective arylation of 2′-deoxyguanosine at N-2 with organoiron complexes
Abstract
2′-Deoxyguanosine has been directly and chemoselectively arylated at the N2-amino function by treatment with tricarbonyl(η5-cyclohexadienylium)iron or tricarbonyl[η5-2-(n-butyl)cyclohexadienylium]iron cations, followed by decomplexation and dehydrogenation, providing a rapid route to N2-aryl-2′-deoxyguanosine nucleosides.