Sulfoxide functionality as a potential carbonium ion mimic in enzyme inhibitor design. Synthesis of a novel inhibitor of 5-enolpyruvylshikimate-3-phosphate synthase
Abstract
A novel 5-enolpyruvylshikimate-3-phosphate synthase (EPSP) inhibitor has been prepared by employing a sulfoxide moiety to mimic the carbocationic centre of the phosphoenolpyruvate (PEP) carbonium ion intermediate.