The first asymmetric total synthesis of thienamycin-like γ-lactam and its analogue
Abstract
The asymmetric total synthesis of thienamycin-like γ-lactam 1 and its analogue 2 has been accomplished by utilising highly diastereoselective alkylation of tin(II) enolate 5 on acyl imine obtained in situ from chiral 3-substituted 5-acetoxypyrrolidin-2-one 3.