Stereoselective synthesis of the 6-phosphono analogue of fructose-6-phosphate
Abstract
The non-isoteric phosphono anlogue 2 of D-fructose-6-phosphate has been synthesized exploiting the reactivity of the fructose derivative 7 which is easily available on a large scale from saccharose; introduction of the phosphonic group by Arbuzov reaction using diphenyl ethyl phosphite followed by deprotection afforded the title compound.