Synthesis of carboranes containing nucleoside bases. Unexpectedly high cytostatic and cytocidal toxicity towards cancer cells
Abstract
5-Carboranyluridine 1, 5-carboranyldeoxyuridine 2 and 5-hydroxymethylcarboranyluridine 3 have been prepared; they show unexpectedly high cytotoxicity towards cancer cells, with IC50 values being ca. 10–5 mol dm–3.