2-Alkyl-1,2-dihydroindol-3-ones are prepared from readily available 1-acetyl-2-methoxy-1,2-dihydroindol-3-one by alkylation reduction with sodium borohydride, and demethoxylation of the resulting 3-hydroxy-2-methoxy-4,3-dihydroindoles with Lewis acids. The stereochemistry of the reduction is also described.
T. Kawasaki, Y. Nonaka, M. Kobayashi and M. Sakamoto, J. Chem. Soc., Perkin Trans. 1, 1991, 2445 DOI: 10.1039/P19910002445
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