Issue 6, 1991

Enantioselective phenylation of prochiral aldehydes using a kinetically formed chiral complex between Grignard–zinc halide reagent and N,N-dibutylnorephedrine

Abstract

Optically active phenylmethanols have been synthesized in good to high enantiomeric excess (up to 82% e.e.) by the enantioselective addition of a kinetically formed complex (between phenyl Grignard–zinc halide and N,N-dibutylnorephedrine) to aliphatic, aromatic and α,β-unsaturated aldehydes.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1991, 1613-1615

Enantioselective phenylation of prochiral aldehydes using a kinetically formed chiral complex between Grignard–zinc halide reagent and N,N-dibutylnorephedrine

K. Soai, Y. Kawase and A. Oshio, J. Chem. Soc., Perkin Trans. 1, 1991, 1613 DOI: 10.1039/P19910001613

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