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Issue 5, 1991
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Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid

Abstract

Extensive alkalimetric anaerobic titrations of cadmium and 2,3-dimercaptopropane-1-sulphonic acid (H3dmps) in aqueous solutions have revealed a family of polynuclear complexes. Over 750 pH measurements [glass electrode, 25°C, I= 0.2 mol dm–3(KNO3)], in 17 separate titrations, were collected with a computer-controlled titrator. The solutions consisted of 0.6–4.0 mmol dm–3 cadmium nitrate and at least a 2.5-fold excess of H3dmps. The functional form of the data was consistent with the equilibrium model [Cd3(dmps)3]3–(log β= 59.9), [Cd(dmps)2]4–(log β= 28.27), [Cd3(dmps)4]6–(log β= 71.9), [Cd5(dmps)6]8–(log β= 114.3) and [Cd7(dmps)8]10–(log β= 156.7). Polynuclear species form below pH 2, but break down to the mononuclear bis complex above pH 7. Simulations suggest that H3dmps can effectively compete for cadmium binding with the sulphydryl-rich protein metallothionein.

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Article type: Paper
DOI: 10.1039/DT9910001189
Citation: J. Chem. Soc., Dalton Trans., 1991,0, 1189-1194

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    Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid

    A. Avdeef and A. R. Chemotti, J. Chem. Soc., Dalton Trans., 1991, 0, 1189
    DOI: 10.1039/DT9910001189

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