Biosynthesis of aspyrone, a metabolite of Aspergillus melleus: advanced precursor studies to identify the product of the polyketide synthase
Abstract
Incorporation studies with deuterium-labelled compounds, using 2H NMR spectroscopy as method of analysis, have shown that a C10 acid, (4E,6E,8E)-3-hydroxydeca-4,6,8-trienoic acid, is incorporated intact into aspyrone when administered to growing cells of Aspergillus melleus.