The ‘cholaphane’1 was synthesized in 26% overall yield from cholic acid and its structure determined by X-ray crystallography; the molecule adopts an open conformation and is able to surround two molecules of tetrahydrofuran.
A. P. Davis, M. G. Orchard, A. M. Z. Slawin and D. J. Williams, J. Chem. Soc., Chem. Commun., 1991, 612 DOI: 10.1039/C39910000612
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