A novel highly stereoselective synthesis of pyrrolidines and their derivatives through thermal cyclization reaction of N-[bis(trimethylsilyl)methyl]-1-aza-1,3-dienes

Abstract

The first example of the thermal intramolecular cyclization of N-[bis(trimethylsilyl)methyl]-1-aza-1,3-dienes to give 5-trimethylsilyl-Δ²-pyrrolines is reported; two straightforward and highly Stereoselective routes to 3,4-disubstituted-5-trimethylsilyl-Δ¹pyrrolines and 3,4-disubstituted-2-trimethylsilylpyrrolidines are also described.