Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: the stereochemical probe
Abstract
The intermediacy of the spiro-pyrrolenine for biosynthesis of uro'gen III is supported by synthesis of both enantiomers of the spiro-lactam 6 followed by demonstration that cosynthetase, the enzyme which forms uro'gen III, is inhibited over twenty times more strongly by one enantiomer than by the other.