The intermediacy of the spiro-pyrrolenine for biosynthesis of uro'gen III is supported by synthesis of both enantiomers of the spiro-lactam 6 followed by demonstration that cosynthetase, the enzyme which forms uro'gen III, is inhibited over twenty times more strongly by one enantiomer than by the other.
M. A. Cassidy, N. Crockett, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1991, 384 DOI: 10.1039/C39910000384
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