(4R,5S)-4-Methyl-5-phenyloxazolidin-2-one was used as a chiral template to construct the 8S and 9S chiral centres of (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (ADDA), the 2S and 3S centres were derived from D-aspartic acid.
M. F. Beatty, C. Jennings-White and M. A. Avery, J. Chem. Soc., Chem. Commun., 1991, 351 DOI: 10.1039/C39910000351
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