Acyclic stereocontrol based on nonchelation-controlled ene reactions with α-haloaldehydes
Abstract
Aluminium(III)-promoted ene reactions with α-haloaldehydes are shown to exhibit a high anti-diastereofacial (non-chelation) selection or syn-diastereoselection to afford an efficient method for preparing stereochemically-defined β-haloalcohols including the 22R-hydroxy side chain unit in steroids.