Issue 7, 1991

Comparison of the measurement of serum cotinine levels by gas chromatography and radioimmunoassay

Abstract

Standard continine solutions, controls and human serum samples containing cotinine have been measured by both radioimmunoassay (RIA) and gas chromatographic (GC) techniques. Cross-checks on standards and controls showed good agreement. However, for samples containing >50 ng ml–1 of cotinine, RIA gave results on average 60% higher than GC. Determinations by using RIA and GC on samples containing <7 ng ml–1 of cotinine gave no significant correlation. The importance of the age of the serum sample has been investigated, and it is suggested that the age may affect the determination when dealing with low levels of cotinine.

Article information

Article type
Paper

Analyst, 1991,116, 691-693

Comparison of the measurement of serum cotinine levels by gas chromatography and radioimmunoassay

I. G. M. Anderson, C. J. Proctor and L. Husager, Analyst, 1991, 116, 691 DOI: 10.1039/AN9911600691

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements