Synthetic approaches to the alkaloids of the ancistrocladaceae: control of the diastereoisomer excess in the synthesis of axially chiral biaryls: a synthesis of (–)-ancistrocladinine
Abstract
An attempt is made to delineate the factors which control the diastereoisomeric excess in the reactions of 2,6-disubstituted phenyl Grignard reagents with the naphthyloxazoline 2; advantage is taken of the results in a synthesis of the Ancistrocladus alkaloid (–)-ancistrocladinine 19.