Asymmetric synthesis of β-phenylserines by condensation of benzaldehyde with zinc(II) and copper(II) complexes of (1R)-3-hydroxymethylenebornan-2-one glycine imines
Abstract
The condensation between benzaldehyde and the zinc(II) and copper(II) complexes of the glycine imines of (1R)-3-hydroxymethylenebornan-2-one in the presence of strong bases has been studied. The diastereo- and enantio-selectivity of the reaction together with the spectroscopic characterization of the metal complexes and the corresponding enolate intermediates are reported.