Synthesis of mesoionic triazoline nucleosides
Abstract
A new type of protected mesoionic triazoline nucleoside was synthesized by the reaction of protected 1,2-dideoxy-hydrazino-D-ribose or 1-deoxy-hydrazino-D-ribose with isothiouronium compounds. The three compounds obtained 10a, 10f and 16a were deprotected with tetrabutylammonium fluoride. They showed no activity against HSV-1 virus.