Reactivity of 2-methylene-1,3-dicarbonyl compounds. Inverse electron-demand Diels–Alder reactions with alkyl vinyl ethers
Abstract
Highly regioselective hetero-Diels–Alder reactions were achieved by reaction of 2-methyene-1,3-dicarbonyl compounds 1 with alkyl vinyl ethers 2. This regioselectivity of the cycloadditions was consistent with the results that could be predicted by considering the frontier orbital of 1.