Mercury cyclisation of hemiamidals containing a stereogenic centre affords diastereoisomeric mixtures of tetrahydro-1,3-oxazin-4-ones or oxazolidin-4-ones, which are easily separated by silica gel chromatography and hydrolysed to give chiral α- and β-hydroxy acids.
G. Cardillo, Md. A. Hashem and C. Tomasini, J. Chem. Soc., Perkin Trans. 1, 1990, 1487 DOI: 10.1039/P19900001487
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