Novel phospholipids have been prepared by a rapid three-step procedure. The oxazaphosphacyclopentane (1) reacts with alcohols to yield cyclic phosphoramidites in high yield. These are oxidised to the corresponding phosphates with N2O4. The phosphates undergo P–N cleavage simply by treatment with water at ambient temperature, to yield phospholipids. Full spectroscopic and analytical data are presented and discussed.
C. McGuigan and B. Swords, J. Chem. Soc., Perkin Trans. 1, 1990, 783 DOI: 10.1039/P19900000783
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