Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deparotection of peptides containing Nπ-bom protected histidine
Abstract
Formaldehyde released during hydrogen fluoride deprotection of peptides containing a histidine residue protected by the Nπ-benzyloxymethyl (Bom) group induces cyclisation of N-terminal cysteine to thiazolidine carboxylic acid (Thz).