4′-Modification of carbocyclic nucleosides: synthesis of 4′-α-fluoro, 4′α-hydroxy and 4′,6′-unsaturated derivatives of the antiviral agent 2′-ara-fluoro carbocyclic guanosine

Abstract

4′-α-Fluoro 13, 4′-α-hydroxy 11, and 4′,6′-unsaturated 15 derivatives of (±) 2′-ara-fluoro carbocylci guanosine 1 are prepared via the 4′,5′-alkene 8.