Formation of novel unsaturated side chain penicillins with isopenicillin N synthase
Abstract
Incubation of δ-L-α-aminoadipoyl-L-cysteinyl-D-propargylglycine (3) and δ-L-α-aminoadipoyl-L-cysteinyl-D-cyanoalanine (4) with Isopenicillin N synthase resulted in the formation of three novel penicillin antibiotics, possessing unsaturated side chains (10), (11), and (12).