The imine formed from 1-acetylferrocene and (R)-(+)-1-phenylethylamine undergoes a highly diastereoselective reduction with sodium borohydride to give, after a single recrystallisation, diastereoisomerically pure (R,R) amine (2a), which has been converted to (R)-(–)-1-ferrocenylethyl acetate in high optical purity (>98%).
D. M. David, L. A. P. Kane-Maguire and S. G. Pyne, J. Chem. Soc., Chem. Commun., 1990, 888 DOI: 10.1039/C39900000888
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