A novel enantiospecific synthesis of (S)-(–)-methyl 6,8-dihydroxyoctanoate, a precursor of (R)-(+)-α-lipoic acid
Abstract
(S)-(–)-Methyl 6,8-dihydroxyoctanoate has been synthesised, with stereocontrolled reduction of methyl 8,8-dimethyl-6-oxo-octanoate using immobilised Bakers yeast as a key step.