Pentafluorophenyl esters for the temporary protection of the α-carboxy group in solid phase glycopeptide synthesis
Abstract
The pentafluorophenyl ester of fluoren-9-ylmethoxycarbonyl serine was found to be stable to glycosylation conditions and the purified glycosylation product was easily incorporated into a solid phase assembly of a nonapeptide analogue of the antifreeze glycopeptides.