Ketene dithioacetals as 1,3-dipolarophiles. Applications to the synthesis of cyclic amino acids
Abstract
Intramolecular azide cycloaddition reactions of ketene dithioacetals provide a new route to cyclic amino acids and a stereoselective synthesis of (2S,3S,4R)-3,4-dihydroxyproline (14) based on this methodology is described.