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Issue 9, 1990
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Determination of the components of analgesic mixtures using high-performance thin-layer chromatography

Abstract

A spectrodensitometric method is described for the determination of the components of two analgesic mixtures. For the first mixture (paracetamol-ascorbic acid-caffeine-phenylephrine), the pharmaceutically active components were separated from each other and closely related degradation products and impurities on high-performance thin-layer chromatography (F254) plates using methylene chloride-ethyl acetate-ethanol-formic acid (3.5 + 2 + 4 + 0.5) and methylene chloride-ethyl acetate-ethanol (5 + 5 + 1) as the developing systems. The other mixture (phenazone-phenacetin-caffeine) was separated efficiently from the degradation products using the same plates and acetonitrile-chloroform (1 + 1) as the mobile phase. The proposed method was used to determine these mixtures in commercial tablets.

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Article information


Analyst, 1990,115, 1181-1184
Article type
Paper

Determination of the components of analgesic mixtures using high-performance thin-layer chromatography

M. El Sadek, A. El Shanawany, A. A. Khier and G. Rücker, Analyst, 1990, 115, 1181
DOI: 10.1039/AN9901501181

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