Jump to main content
Jump to site search

Issue 9, 1990
Previous Article Next Article

Adsorptive stripping voltammetric determination of pipemidic acid in human urine

Abstract

The electrochemical behaviour of pipemidic acid {8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)- pyrido[2,3-d]pyrimidine-6-carboxylic acid}, a well known antimicrobial agent used for urinary infections, was investigated by linear-sweep, differential-pulse and square-wave voltammetry at a hanging mercury drop electrode. Two reduction processes were observed in Britton-Robinson buffers at acid pH, whereas only one or two processes were observed in alkaline solutions, dependent on the pH of the buffer employed. Adsorptive effects were used to accumulate the drug on to the electrode. The adsorbed species were measured voltammetrically by using a cathodic process appearing at –0.76 V in 0.1 M HClO4. Linear calibratioin graphs were obtained in the range 2.5 × 10–7M. A simple procedure of extraction was employed for the determination of the drug in urine samples.

Back to tab navigation

Article type: Paper
DOI: 10.1039/AN9901501215
Analyst, 1990,115, 1215-1217

  •   Request permissions

    Adsorptive stripping voltammetric determination of pipemidic acid in human urine

    M. Telting-Diaz, A. J. M. Ordieres, A. C. Garcia, P. T. Blanco, D. Diamond and M. R. Smyth, Analyst, 1990, 115, 1215
    DOI: 10.1039/AN9901501215

Search articles by author

Spotlight

Advertisements