Synthesis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its enantiomers
Abstract
Convenient syntheses of (R/S)-3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (pyridoglutethimide) and its enantiomers are described; aromatase inhibitory activity was almost entirely confined to the 3R-enantiomer.