α-Metallation of tetrahydroquinoline and indoline via their lithium carbamates: a versatile one-pot procedure
Abstract
1,2,3,4-Tetrahydroquinoline and Indoline as their lithium carbamates undergo α-metallation with a ButLi–KOBut mixture. The resulting α-metallo species react with carbonyl electrophiles to give the α-alkylated secondary amines in an overall one-pot procedure.