Synthesis of compounds active against HIV: preparation of 6′-fluorocarbocyclic AZT (AZT = 3′-deoxy-3′-azidothymidine)
Abstract
The carbocyclic nucleosides (2) and (3) have been prepared and tested for anti-HIV activity: AZT-triphosphate (20)(AZT = 3′-deoxy-3′-azidothymidine) was synthesized by a new procedure and the same method was used to make the novel triphosphate (21).