An orally potent human renin inhibitor (1a) containing a novel amino acid, (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid named cyclohexylnorstatine, has been designed from the angiotensinogen transition-state and synthesized.
K. Iizuka, T. Kamijo, H. Harada, K. Akahane, T. Kubota, H. Umeyama and Y. Kiso, J. Chem. Soc., Chem. Commun., 1989, 1678 DOI: 10.1039/C39890001678
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